Wheat OIT- FAQ 

Wheat Oral Immunotherapy


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Oral Immunotherapy

Oral immunotherapy explained 

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Allergy & Asthma Institute of SE Michigan

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Wheat Oral Immunotherapy - FAQ


1. Q. How long will the entire process take?

A. The first day procedure will take about 7-8 hours. If there are no reactions during the oral immunotherapy, you will be eating wheat in about 4-5 months.

2. Q. Should routine allergy medications be stopped before the first day procedure?

A. No.

3. Q. What is the timeline for the months after the first day?

A. Exactly how it will go depends on each individual child. If everything goes well, wheat flour will be eaten by the second month and wheat bread will be eaten by the fourth month. At that point, the frequency of dosing will be weaned. By five months, if there are no reactions, only one dose per day will be needed.

4. Q. How often can the dose be increased?

A. Early in the process there must be at least five full days of home dosing between office visits for dose increases. For the last nine doses the interval between dose changes is six days.

5. Q. What time of day should home doses be given?

A. For Once a day dosing, try to make the interval between wheat doses no less than 10 hours.

6. Q. How long should my child stay awake after the evening dose?

A. Children should be observed for at least one hour after the dose is given. They should not be allowed to sleep during this time.

7. Q. What about home dosing on the day of the office visit for dose increase?

A. There should be at least 10 hours and no more than 15 hours between doses. NEVER increase the dose at home.

8. Q. If there is a reaction at home, what should I do?

A. Treat the reaction the same way you would any food reaction; antihistamine if there is just rash, Epi-pen if there are other symptoms of anaphylaxis. If there is just one or a few hives, DO NOT give antihistamine for the first hour so we can see if the reaction progresses. If the hives are increasing, give antihistamine. Call us after the appropriate immediate intervention. We will give instructions on future dosing.

9. Q. What if we are flying when the dose is due?

A. Do not administer the dose less than one hour before boarding and do not administer the dose while flying. If there are scheduling conflicts while traveling, give a dose just  before leaving and just after returning.

10. Q. At what point can we buy our own food?

A. Once dosing with whole wheat bread begins parents will be responsible for buying bread for home dosing.

11. Q. Does the wheat solution need refrigeration?

A. There are no preservatives in the wheat flour dilutions. They should be kept cold.

12. Q. What do I do if refrigeration is not maintained or if it smells or tastes different?

A. If the sample sits out for more than 30 minutes or if it appears to have spoiled, the food dilutions must be replaced. Please call the office. If replacement is made during regular office hours, there is no charge. If replacement must be made at night or on a weekend or holiday there will be a charge of $50. This fee cannot be charged to your insurance.

13. Q. What if I need additional doses and I am out of town?

A. Call as soon as you know you need more. You must be able to tell us what the concentration and amount of the current dose is. We can ship doses to you on ice via FedEx. If this is done during regular office hours, there will be a charge of $25 plus the FedEx charge for this service. If a staff member needs to come in at night, on a weekend or holiday, there will be an additional charge of $50 (I.E., $75 plus the FedEx charge). This fee cannot be charged to your insurance.

14. Q. What if my child is sick and can’t take the doses on schedule?

A. If there is a gap of more than 15 hours between doses, call before giving the next dose. If it is less than 15 hours, pick up on the standard schedule.

15. Q. What about masking the taste of the wheat flour solution?

A. Taste is personal; experiment. Try drink powder (Kool-Aide, Crystal Light), chocolate or another beverage. Small volumes could be mixed with a semi-solid food such as apple sauce or mashed potato but it is important that the entire dose of oral immunotherapy mixture be taken. If the total amount gets too large, it will be hard to get it all down.

16. Q. When can foods containing wheat be introduced into the regular diet?

A. Foods containing wheat may be added to the diet once the oral immunotherapy process is complete.

17. Q. What is the goal of this process?

A. The number one goal is safety; to allow the patient to eat the problem food without thinking about it.

18. Q. What is the follow up schedule when a full portion of wheat is being eaten?

A. When the full dose has been reached, there should be follow up at one week, one month and then three months after that.

19. Q. When dosing is reduced to once a day, is the time of day important?

A. Time of day is not important but the amount of time between doses is important. We have achieved a delicate balance that depends on a certain amount of wheat being in the system at all times. You should try to give the once a day dose at the same time every day (24 plus or minus two hours).

20. Q. Does my child need to avoid exercise during the oral immunotherapy process?

A. Exercise should be avoided for at least two hours after wheat dosing, but it is ideal to avoid exercise for four hours after dosing. Exercise following wheat dosing increases the chance of a reaction.

21. Q. Can two oral immunotherapy foods, one on maintenance dose and one on increasing dose be given at the same time?

A. Yes.

22. Q. How much wheat can/must my child eat following completion of the oral immunotherapy process?

A. Your child must ingest 2 slices of whole wheat bread daily as a maintenance dose following completion of the oral immunotherapy process, but your child may also consume as much wheat as he/she would like in addition to that. We will have regularly scheduled follow-up appointments, and if the time comes when the frequency of the maintenance dose changes, we will let you know. Until then, your child must continue the daily maintenance dose.

23. Q. How soon after completion of the oral immunotherapy can a food challenge be done for another food?

A. May do a food challenge for a different food 1 week after completing oral immunotherapy.

24. Q. How soon after completion of the oral immunotherapy can a second oral immunotherapy be performed for another food?

A. May do oral immunotherapy for a different food 1 month after completing oral immunotherapy.

25. Q. How is the food oral immunotherapy billed and what does it cost?

A. The procedure is separate from office visits. The day one procedure is billed as desensitization. Subsequent doses are billed as a challenge (significantly lower cost than desensitization). The actual reimbursement varies by insurance plan.

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